VThunter
a database for single-cell screening of virus target cells in animal kingdom
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Rat

Scientific Name: Rattus norvegicus

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Euarchontoglires-> Glires-> Rodentia-> Myomorpha-> Muroidea-> Muridae-> Murinae

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Feline coronavirus

Family: Coronaviridae

Receptor: ANPEP

Receptor ANPEP information

Summary: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020] [NCBI]  [Proteinatlas]

Data Source

Data set information

Project Date Technology Tissue Condition Cell PMID/DOI
Vthunter_1001 2019.12 10X Genomics Lung Normal 5029 Link
Vthunter_1002 2019.12 10X Genomics Lung Normal 5924 Link
Vthunter_1009 2017.11 Fluidigm C1 UrogenitalSinus Normal 114 Link
Vthunter_110073 2019.12 MARS-seq TotalBrain Normal 2304 Link
Featureplot of receptors

Featureplot of receptors

mRNA expression of ANPEP in human tissues   [NCBI]

Expression: Biased expression in duodenum (RPKM 1193.1), small intestine (RPKM 1007.5) and 5 other tissues?

Protein expression of ANPEP in human tissues   [Proteinatlas]